![]() ![]() Of the 15 cases, 13 were female, with a mean age at diagnosis of 56.8 years. In these cases, abnormal receptor screening was performed by means of stimulation tests, with a plasma cortisol increase of ≥25% from baseline being considered pathologic. Material and methodsĪ multicentre descriptive study of a 15-case series of AICS with nodular adrenal hyperplasia (study period: 2002–2016). Our aim is to study the presence of abnormal receptors in subjects diagnosed with AICS with nodular adrenal hyperplasia in a 14-year period (2002–2016), as well as its clinical–biological and evolutive characteristics. ACTH-independent Cushing's syndrome (AICS) accounts for 15–20% of cases of Cushing's syndrome, with <1% due to abnormal receptors.
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